Rat Anti-Mouse CD223 Antibody (S-R624)

Name: Rat Anti-Mouse CD223 Antibody (S-R624)S0B5106
Brand: Starter/斯達(dá)特
Price: 600 CNY
Availability: InStock

產(chǎn)品型號(hào)：S0B5106

更新時(shí)間：2025-10-08

廠商性質(zhì)：生產(chǎn)廠家

訪問量：114

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抗體/抗原

ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對(duì)抗體病理/IHC抗體

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產(chǎn)品介紹

CD223, also known as Lymphocyte Activation Gene-3 （LAG-3）, is a type I transmembrane protein and a member of the immunoglobulin superfamily. It is an inhibitory immune checkpoint receptor that is selectively expressed on activated T cells, regulatory T cells, natural killer （NK） cells, and plasmacytoid dendritic cells. LAG-3 shares significant homology with CD4, particularly in its extracellular region, which contains four immunoglobulin-like domains. The molecule has a high-affinity binding to MHC class II molecules, which is its primary ligand, and this interaction negatively regulates T cell activation, proliferation, and cytokine production. Additionally, LAG-3 is involved in the negative regulation of regulatory T cell differentiation and the activation of plasmacytoid dendritic cells. In the context of cancer, LAG-3 is upregulated on tumor-infiltrating lymphocytes and is associated with tumor immune evasion, making it a promising target for cancer immunotherapy.

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