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產(chǎn)品中心抗體/抗原流式抗體S0B5118APC-Cy7 Rat Anti-Mouse CD8α Antibody (S-R540)
產(chǎn)品型號：S0B5118
更新時間：2025-10-08
廠商性質(zhì)：生產(chǎn)廠家
訪問量：124
服務(wù)熱線15855403091
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CD8α is a crucial immune glycoprotein that plays a key role in coordinating immune responses against both external and internal threats. It serves as a co-receptor for the MHC class I-peptide complex, facilitating the recognition of antigens derived from cytosolic proteins by T cells. CD8α can form either a homodimer （CD8αα） or a heterodimer with CD8β （CD8αβ）, both of which interact with the T cell receptor （TCR） and MHC class I molecules to recruit the LCK kinase and initiate multiple signaling pathways. This interaction is essential for the activation of cytotoxic T lymphocytes （CTLs）, which are critical for eliminating infected or abnormal cells. Additionally, CD8α is involved in the development and function of intraepithelial lymphocytes （IELs） in the gut, contributing to the maintenance of mucosal barriers.
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