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產(chǎn)品中心抗體/抗原流式抗體S0B5421Alexa Fluor? 647 Mouse Anti-Human CD47 Antibody (S-823-72)
產(chǎn)品型號(hào)：S0B5421
更新時(shí)間：2025-10-09
廠商性質(zhì)：生產(chǎn)廠家
訪問量：119
服務(wù)熱線15855403091
產(chǎn)品分類
CD47, also known as integrin-associated protein, is a ubiquitously expressed cell surface receptor that belongs to the immunoglobulin superfamily. It is widely known for its role in preventing macrophage-mediated phagocytosis by interacting with signal regulatory protein alpha （SIRPα） on phagocytic cells. This “don’t eat me" signal is crucial for the survival of healthy cells, but cancer cells often overexpress CD47 to evade immune attack. In addition to its role in immune regulation, CD47 is involved in various cellular processes, including cell adhesion, migration, and the regulation of autophagy and cell death. For instance, it can regulate the migration of immune cells like neutrophils and dendritic cells, and its interaction with thrombospondin-1 （TSP-1） can induce apoptosis in certain cell types. Due to its significant role in cancer immunotherapy, CD47 has become an important target for developing new therapeutic strategies.
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