Alexa Fluor? 647 Rat Anti-Mouse CD274/B7-H1/PD-L1 Antibody (S-R072)

Name: Alexa Fluor? 647 Rat Anti-Mouse CD274/B7-H1/PD-L1 Antibody (S-R072)S0B5429
Brand: Starter/斯達(dá)特
Price: 1000 CNY
Availability: InStock

產(chǎn)品型號(hào)：S0B5429

更新時(shí)間：2025-10-09

廠商性質(zhì)：生產(chǎn)廠家

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產(chǎn)品介紹

PD-L1, also known as CD274 or B7-H1, is a type I transmembrane glycoprotein and a member of the B7 family. It was first identified in 1999. PD-L1 plays a crucial role in immune regulation by binding to PD-1 on T cells, inhibiting their activation and proliferation through multiple pathways, thus dampening tumor-reactive T cell responses. This protein is widely expressed in various cells, including antigen-presenting cells, activated T cells, B cells, and some non-hematopoietic cells. Its expression is often upregulated in tumor cells, contributing to immune evasion. Targeting PD-L1 has become a major strategy in cancer immunotherapy, with several antibodies developed to block its interaction with PD-1, enhancing anti-tumor immunity.

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