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產(chǎn)品中心抗體/抗原偶聯(lián)抗體S0B1536ErbB2 Recombinant Rabbit mAb (Alexa Fluor? 555 Conjugate) (S-069-57)
產(chǎn)品型號(hào)：S0B1536
更新時(shí)間：2025-10-10
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Receptor tyrosine-protein kinase erbB-2 is a protein that in humans is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B. The human protein is also frequently referred to as HER2 （human epidermal growth factor receptor 2） or CD340 （cluster of differentiation 340）. HER2 is a member of the human epidermal growth factor receptor （HER/EGFR/ERBB） family. But contrary to other member of the ERBB family, HER2 does not directly bind ligand. HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients.
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