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產(chǎn)品中心抗體/抗原流式抗體S0B5037Mouse Anti-Human CD184 Antibody (S-R635)
產(chǎn)品型號：S0B5037
更新時間：2025-10-08
廠商性質：生產(chǎn)廠家
訪問量：108
服務熱線15855403091
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相關文章
CD184, also known as CXCR4, is a G protein-coupled receptor with seven transmembrane domains that serves as the receptor for stromal cell-derived factor-1 （SDF-1, also known as CXCL12）. It is widely expressed in various tissues, including peripheral blood leukocytes, spleen, thymus, bone marrow, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, and endothelial cells. CXCR4 plays crucial roles in multiple physiological processes, such as cell migration, hematopoiesis, vascularization, neural development, and wound healing. It also acts as a co-receptor for T-cell tropic strains of HIV-1, facilitating viral entry into CD4+ cells. In cancer, CXCR4 is overexpressed in many tumor types and is associated with increased invasiveness, metastasis, and poor prognosis. Additionally, CXCR4 is involved in the homing of hematopoietic stem cells to the bone marrow and the retention of aged neutrophils.
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